| PHUMAN F2RL1 GPR11 PAR2 (a.a. 28-397) |
| Homo sapiens F2RL1 GPR11 PAR2 Swiss Prot# |
| P55085 |
| Homo sapiens F2RL1 GPR11 PAR2 Protein names |
| Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2] |
| Homo sapiens F2RL1 GPR11 PAR2 Gene names |
| F2RL1 GPR11 PAR2 |
| Organism |
| Homo sapiens (Human) |
| Homo sapiens F2RL1 GPR11 PAR2 Entry name |
| PAR2_HUMAN |
| Homo sapiens F2RL1 GPR11 PAR2 Codon optimized cDNA Clone |
| Homo sapiens F2RL1 GPR11 PAR2 cDNA Cat# |
| RPQ-1842-0018 |
| cDNA Tag |
| cDNA Homo sapiens F2RL1 GPR11 PAR2 contains A 6x histidine tag |
| Condon optimized Homo sapiens F2RL1 GPR11 PAR2 cDNA Formulation |
| Liquid |
| Condon optimized Homo sapiens F2RL1 GPR11 PAR2 cDNA Storage |
| Ship at Room temperature. Storage at -20°C to -80°C Upon receipt. Avoid repeated freeze-thaw |
| Condon optimized Homo sapiens F2RL1 GPR11 PAR2 cDNA Applications |
| Applications:
1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.
2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Homo sapiens F2RL1 GPR11 PAR2 Protein |
| Recombinant Homo sapiens F2RL1 GPR11 PAR2 Protein Cat# |
| PQ-1842-0018 |
| Homo sapiens F2RL1 GPR11 PAR2 Protein Source |
| Recombinant protein |
| Recombinant Homo sapiens F2RL1 GPR11 PAR2 Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant Homo sapiens F2RL1 GPR11 PAR2 Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant Homo sapiens F2RL1 GPR11 PAR2 Protein Activity |
| NA |
| Recombinant protein Tag |
| Recombinant Homo sapiens F2RL1 GPR11 PAR2 Contains A 6x histidine tag |
| Recombinant Homo sapiens F2RL1 GPR11 PAR2 Protein Formulation |
| Liquid |
| Recombinant Homo sapiens F2RL1 GPR11 PAR2 Protein Storage |
| Ship at 4°C. Storage at -20°C to -80°C Upon receipt. Avoid repeated freeze-thaw |
| Homo sapiens F2RL1 GPR11 PAR2 Protein family |
| - |
| Homo sapiens F2RL1 GPR11 PAR2 Subcellular locations |
| Cell membrane; Multi-pass membrane protein. |
| Homo sapiens F2RL1 GPR11 PAR2 FUNCTION According to UniProtKB Swiss Prot |
| FUNCTION: Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF- |
kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can |
| signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway |
| epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha |
| subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which |
| internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves |
| dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and |
| chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the |
| JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During |
| inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts |
| synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. |
| Homo sapiens F2RL1 GPR11 PAR2 3D structure databases |
| ModBase |
| Homo sapiens F2RL1 GPR11 PAR2 Protein protein interaction databases |
| STRING |
| Homo sapiens F2RL1 GPR11 PAR2 Proteomic databases |
| PRIDE |
| Homo sapiens F2RL1 GPR11 PAR2 Organism specific databases |
| CTD |
MGI |
| FOR in vitro RESEARCH USE ONLY |
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