| HUMAN PIK3CD (a.a.25-345) |
| Homo sapiens PIK3CD Swiss Prot# |
| O00329 |
| Homo sapiens PIK3CD Protein names |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase |
subunit p110-delta) (p110delta) |
| Homo sapiens PIK3CD Gene names |
| PIK3CD |
| Organism |
| Homo sapiens (Human) |
| Homo sapiens PIK3CD Entry name |
| PK3CD_HUMAN |
| Homo sapiens PIK3CD Codon optimized cDNA Clone |
| Homo sapiens PIK3CD cDNA Cat# |
| RPQ-1842-0025 |
| cDNA Tag |
| cDNA Homo sapiens PIK3CD contains A 6x histidine tag |
| Condon optimized Homo sapiens PIK3CD cDNA Formulation |
| Liquid |
| Condon optimized Homo sapiens PIK3CD cDNA Storage |
| Ship at Room temperature. Storage at -20°C to -80°C Upon receipt. Avoid repeated freeze-thaw |
| Condon optimized Homo sapiens PIK3CD cDNA Applications |
| Applications:
1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.
2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Homo sapiens PIK3CD Protein |
| Recombinant Homo sapiens PIK3CD Protein Cat# |
| PQ-1842-0025 |
| Homo sapiens PIK3CD Protein Source |
| Recombinant protein |
| Recombinant Homo sapiens PIK3CD Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant Homo sapiens PIK3CD Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant Homo sapiens PIK3CD Protein Activity |
| NA |
| Recombinant protein Tag |
| Recombinant Homo sapiens PIK3CD Contains A 6x histidine tag |
| Recombinant Homo sapiens PIK3CD Protein Formulation |
| Liquid |
| Recombinant Homo sapiens PIK3CD Protein Storage |
| Ship at 4°C. Storage at -20°C to -80°C Upon receipt. Avoid repeated freeze-thaw |
| Homo sapiens PIK3CD Protein family |
| - |
| Homo sapiens PIK3CD Subcellular locations |
| Cytoplasm. |
| Homo sapiens PIK3CD FUNCTION According to UniProtKB Swiss Prot |
| FUNCTION: Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 |
and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell |
| proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in |
| response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR |
| leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, |
| CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine |
| production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor |
| (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK |
| phosphorylation and increased PI3K activity. |
| Homo sapiens PIK3CD 3D structure databases |
| ModBase |
| Homo sapiens PIK3CD Protein protein interaction databases |
| STRING |
| Homo sapiens PIK3CD Proteomic databases |
| PRIDE |
| Homo sapiens PIK3CD Organism specific databases |
| CTD |
MGI |
| FOR in vitro RESEARCH USE ONLY |
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