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Human Egl nine homolog 1 (a.a.1-426)
EGLN1 Swiss Prot#
Q9GZT9
EGLN1 Protein names
Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl

hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (Prolyl

hydroxylase domain-containing protein 2) (PHD2) (SM-20)
EGLN1 Gene names
EGLN1 C1orf12 PNAS-118 PNAS-137
Organism
Human
EGLN1 Entry name
EGLN1_HUMAN
EGLN1 Codon optimized cDNA Clone
EGLN1 CDNA Cat#
RPS0167
cDNA Tag
cDNA EGLN1 Contains A 6x histidine tag
Condon optimized EGLN1 CDNA Formulation
Liquid
Condon optimized EGLN1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized EGLN1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant EGLN1 Protein
Recombinant EGLN1 Protein Cat#
PS0167
EGLN1 Protein Source
Recombinant protein.
Recombinant EGLN1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant EGLN1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant EGLN1 Protein Activity
N/A
Recombinant protein Tag
Recombinant EGLN1 contains A 6x histidine tag
Recombinant EGLN1 Protein Formulation
Liquid
Recombinant EGLN1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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EGLN1 Protein family
-
EGLN1 Subcellular locations
-
EGLN1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in

hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at

'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen

sensor and, under normoxic conditions, targets HIF through the

hydroxylation for proteasomal degradation via the von Hippel-Lindau

ubiquitination complex.
EGLN1 Sequence databases
EMBL DDBJ GenBank
EGLN1 3D structure databases
ModBase
EGLN1 Protein-protein interaction databases
STRING
EGLN1 Proteomic databases
PRIDE
EGLN1 Genome annotation databases
Ensembl GeneID KEGG UCSC
EGLN1 Organism specific databases
CTD MGI
EGLN1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
EGLN1 Gene expression databases
Bgee ArrayExpress Genevestigator
EGLN1 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY