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Human Eyes absent homolog 3 (a.a.1-573)
EYA3 Swiss Prot#
Q99504
EYA3 Protein names
Eyes absent homolog 3 (EC 3.1.3.48)
EYA3 Gene names
EYA3
Organism
Human
EYA3 Entry name
EYA3_HUMAN
EYA3 Codon optimized cDNA Clone
EYA3 CDNA Cat#
RPS0210
cDNA Tag
cDNA EYA3 Contains A 6x histidine tag
Condon optimized EYA3 CDNA Formulation
Liquid
Condon optimized EYA3 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized EYA3 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant EYA3 Protein
Recombinant EYA3 Protein Cat#
PS0210
EYA3 Protein Source
Recombinant protein.
Recombinant EYA3 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant EYA3 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant EYA3 Protein Activity
N/A
Recombinant protein Tag
Recombinant EYA3 contains A 6x histidine tag
Recombinant EYA3 Protein Formulation
Liquid
Recombinant EYA3 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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EYA3 Protein family
HAD-like hydrolase superfamily, EYA family
EYA3 Subcellular locations
Cytoplasm. Nucleus.
EYA3 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-

142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone

H2AX plays a central role in DNA repair and acts as a mark that

distinguishes between apoptotic and repair responses to genotoxic stress.

Promotes efficient DNA repair by dephosphorylating H2AX, promoting the

recruitment of DNA repair complexes containing MDC1. Its function as

histone phosphatase probably explains its role in transcription regulation

during organogenesis. Coactivates SIX1, and seems to coactivate SIX2,

SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts

by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-

DACH1 complex and seems to be dependent on EYA3 phosphatase activity

(By similarity). May be involved in development of the eye.
EYA3 Sequence databases
EMBL DDBJ GenBank
EYA3 3D structure databases
ModBase
EYA3 Protein-protein interaction databases
STRING
EYA3 Proteomic databases
PRIDE
EYA3 Genome annotation databases
Ensembl GeneID KEGG UCSC
EYA3 Organism specific databases
CTD MGI
EYA3 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
EYA3 Gene expression databases
Bgee ArrayExpress Genevestigator
EYA3 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY