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Human Krueppel-like factor 1 (a.a.1-362)
KLF1 Swiss Prot#
Q13351
KLF1 Protein names
Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF)
KLF1 Gene names
KLF1 EKLF
Organism
Human
KLF1 Entry name
KLF1_HUMAN
KLF1 Codon optimized cDNA Clone
KLF1 CDNA Cat#
RPS0417
cDNA Tag
cDNA KLF1 Contains A 6x histidine tag
Condon optimized KLF1 CDNA Formulation
Liquid
Condon optimized KLF1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized KLF1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant KLF1 Protein
Recombinant KLF1 Protein Cat#
PS0417
KLF1 Protein Source
Recombinant protein.
Recombinant KLF1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant KLF1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant KLF1 Protein Activity
N/A
Recombinant protein Tag
Recombinant KLF1 contains A 6x histidine tag
Recombinant KLF1 Protein Formulation
Liquid
Recombinant KLF1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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KLF1 Protein family
Krueppel C2H2-type zinc-finger protein family
KLF1 Subcellular locations
Nucleus.
KLF1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Transcription regulator of erythrocyte development that probably

serves as a general switch factor during erythropoiesis. Is a dual regulator

of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin

gene promoter and acts as a preferential activator of this gene.

Furthermore, it binds to the BCL11A promoter and activates expression of

BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual

activity ensures that, in most adults, fetal hemoglobin levels are low. Able

to activate CD44 and AQP1 promoters. When sumoylated, acts as a

transcriptional repressor by promoting interaction with CDH2/MI2beta and

also represses megakaryocytic differentiation (By similarity).
KLF1 Sequence databases
EMBL DDBJ GenBank
KLF1 3D structure databases
ModBase
KLF1 Protein-protein interaction databases
STRING
KLF1 Proteomic databases
PRIDE
KLF1 Genome annotation databases
Ensembl GeneID KEGG UCSC
KLF1 Organism specific databases
CTD MGI
KLF1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
KLF1 Gene expression databases
Bgee ArrayExpress Genevestigator
KLF1 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY