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Human Nuclear receptor subfamily 2 group F member 6 (a.a.1-404)
NR2F6 Swiss Prot#
P10588
NR2F6 Protein names
Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2)

(EAR-2)
NR2F6 Gene names
NR2F6 EAR2 ERBAL2
Organism
Human
NR2F6 Entry name
NR2F6_HUMAN
NR2F6 Codon optimized cDNA Clone
NR2F6 CDNA Cat#
RPS0580
cDNA Tag
cDNA NR2F6 Contains A 6x histidine tag
Condon optimized NR2F6 CDNA Formulation
Liquid
Condon optimized NR2F6 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized NR2F6 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant NR2F6 Protein
Recombinant NR2F6 Protein Cat#
PS0580
NR2F6 Protein Source
Recombinant protein.
Recombinant NR2F6 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant NR2F6 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant NR2F6 Protein Activity
N/A
Recombinant protein Tag
Recombinant NR2F6 contains A 6x histidine tag
Recombinant NR2F6 Protein Formulation
Liquid
Recombinant NR2F6 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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NR2F6 Protein family
Nuclear hormone receptor family, NR2 subfamily
NR2F6 Subcellular locations
Nucleus.
NR2F6 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Transcription factor predominantly involved in transcriptional

repression. Binds to promoter/enhancer response elements that contain the

imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings

which are also recognized by other nuclear hormone receptors. Involved in

modulation of hormonal responses. Represses transcriptional activity of

the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the

renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the

triiodothyronine-dependent and -independent transcriptional activity of the

thyroid hormone receptor gene in a cell type-specific manner. The

corepressing function towards thyroid hormone receptor beta/THRB

involves at least in part the inhibition of THRB binding to triiodothyronine

response elements (TREs) by NR2F6. Inhibits NFATC transcription factor

DNA binding and subsequently its transcriptional activity. Acts as

transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T

cells and may be involved in induction and/or maintenance of peripheral

immunological tolerance and autoimmunity. Involved in development of

forebrain circadian clock; is required early in the development of the locus

coeruleus (LC).
NR2F6 Sequence databases
EMBL DDBJ GenBank
NR2F6 3D structure databases
ModBase
NR2F6 Protein-protein interaction databases
STRING
NR2F6 Proteomic databases
PRIDE
NR2F6 Genome annotation databases
Ensembl GeneID KEGG UCSC
NR2F6 Organism specific databases
CTD MGI
NR2F6 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
NR2F6 Gene expression databases
Bgee ArrayExpress Genevestigator
NR2F6 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY