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Human PRKC apoptosis WT1 regulator protein (a.a.1-340)
PAWR Swiss Prot#
Q96IZ0
PAWR Protein names
PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4

protein) (Par-4)
PAWR Gene names
PAWR PAR4
Organism
Human
PAWR Entry name
PAWR_HUMAN
PAWR Codon optimized cDNA Clone
PAWR CDNA Cat#
RPS0604
cDNA Tag
cDNA PAWR Contains A 6x histidine tag
Condon optimized PAWR CDNA Formulation
Liquid
Condon optimized PAWR CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized PAWR cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant PAWR Protein
Recombinant PAWR Protein Cat#
PS0604
PAWR Protein Source
Recombinant protein.
Recombinant PAWR Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PAWR Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PAWR Protein Activity
N/A
Recombinant protein Tag
Recombinant PAWR contains A 6x histidine tag
Recombinant PAWR Protein Formulation
Liquid
Recombinant PAWR Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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PAWR Protein family
-
PAWR Subcellular locations
Cytoplasm. Nucleus.
PAWR FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Pro-apoptopic protein capable of selectively inducing apoptosis

in cancer cells, sensitizing the cells to diverse apoptotic stimuli and

causing regression of tumors in animal models. Induces apoptosis in

certain cancer cells by activation of the Fas prodeath pathway and

coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the

transcriptional activation and augments the transcriptional repression

mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its

interaction with WT1. Seems also to be a transcriptional repressor by itself.

May be directly involved in regulating the amyloid precursor protein (APP)

cleavage activity of BACE1.
PAWR Sequence databases
EMBL DDBJ GenBank
PAWR 3D structure databases
ModBase
PAWR Protein-protein interaction databases
STRING
PAWR Proteomic databases
PRIDE
PAWR Genome annotation databases
Ensembl GeneID KEGG UCSC
PAWR Organism specific databases
CTD MGI
PAWR Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PAWR Gene expression databases
Bgee ArrayExpress Genevestigator
PAWR Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY