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Human Pituitary homeobox 3 (a.a.1-302)
PITX3 Swiss Prot#
O75364
PITX3 Protein names
Pituitary homeobox 3 (Paired-like homeodomain transcription factor 3)

(Homeobox protein PITX3)
PITX3 Gene names
PITX3 PTX3
Organism
Human
PITX3 Entry name
PITX3_HUMAN
PITX3 Codon optimized cDNA Clone
PITX3 CDNA Cat#
RPS0633
cDNA Tag
cDNA PITX3 Contains A 6x histidine tag
Condon optimized PITX3 CDNA Formulation
Liquid
Condon optimized PITX3 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized PITX3 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant PITX3 Protein
Recombinant PITX3 Protein Cat#
PS0633
PITX3 Protein Source
Recombinant protein.
Recombinant PITX3 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PITX3 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PITX3 Protein Activity
N/A
Recombinant protein Tag
Recombinant PITX3 contains A 6x histidine tag
Recombinant PITX3 Protein Formulation
Liquid
Recombinant PITX3 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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PITX3 Protein family
Paired homeobox family, Bicoid subfamily
PITX3 Subcellular locations
Nucleus.
PITX3 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Transcriptional regulator which is important for the

differentiation and maintenance of meso-diencephalic dopaminergic (mdDA)

neurons during development. In addition to its importance during

development, it also has roles in the long-term survival and maintenance of

the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of

genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for

development of mdDA neurons. Acts by decreasing the interaction of

NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through

histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target

genes in a repressed deacetylated state. Essential for the normal lens

development and differentiation. Plays a critical role in the maintenance of

mitotic activity of lens epithelial cells, fiber cell differentiation and in the

control of the temporal and spatial activation of fiber cell-specific

crystallins. Positively regulates FOXE3 expression and negatively

regulates PROX1 in the anterior lens epithelium, preventing activation of

CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial

cells in cell cycle (By similarity).
PITX3 Sequence databases
EMBL DDBJ GenBank
PITX3 3D structure databases
ModBase
PITX3 Protein-protein interaction databases
STRING
PITX3 Proteomic databases
PRIDE
PITX3 Genome annotation databases
Ensembl GeneID KEGG UCSC
PITX3 Organism specific databases
CTD MGI
PITX3 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PITX3 Gene expression databases
Bgee ArrayExpress Genevestigator
PITX3 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY