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Human E3 SUMO-protein ligase CBX4 (a.a.1-560)
CBX4 Swiss Prot#
O00257
CBX4 Protein names
E3 SUMO-protein ligase CBX4 (Chromobox protein homolog 4) (Polycomb 2

homolog) (Pc2) (hPc2)
CBX4 Gene names
CBX4
Organism
Human
CBX4 Entry name
CBX4_HUMAN
CBX4 Codon optimized cDNA Clone
CBX4 CDNA Cat#
RPS0067
cDNA Tag
cDNA CBX4 Contains A 6x histidine tag
Condon optimized CBX4 CDNA Formulation
Liquid
Condon optimized CBX4 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized CBX4 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant CBX4 Protein

Recombinant CBX4 Protein Cat#
PS0067
CBX4 Protein Source
Recombinant protein.
Recombinant CBX4 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant CBX4 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant CBX4 Protein Activity
N/A
Recombinant protein Tag
Recombinant CBX4 contains A 6x histidine tag
Recombinant CBX4 Protein Formulation
Liquid
Recombinant CBX4 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Place Order for Recombinant CBX4 Protein or cDNA
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CBX4 Protein family
-
CBX4 Subcellular locations
Nucleus.
CBX4 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by

UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1

complex, a complex required to maintain the transcriptionally repressive

state of many genes, including Hox genes, throughout development. PcG

PRC1 complex acts via chromatin remodeling and modification of histones;

it mediates monoubiquitination of histone H2A 'Lys-119', rendering

chromatin heritably changed in its expressibility.
CBX4 Sequence databases
EMBL DDBJ GenBank
CBX4 3D structure databases
ModBase
CBX4 Protein-protein interaction databases
STRING
CBX4 Proteomic databases
PRIDE
CBX4 Genome annotation databases
Ensembl GeneID KEGG UCSC
CBX4 Organism specific databases
CTD MGI
CBX4 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
CBX4 Gene expression databases
Bgee ArrayExpress Genevestigator
CBX4 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY