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Human E3 ubiquitin-protein ligase RING2 (a.a.1-336)
RNF2 Swiss Prot#
Q99496
RNF2 Protein names
E3 ubiquitin-protein ligase RING2 (EC 6.3.2.-) (RING finger protein 2) (RING

finger protein 1B) (RING1b) (RING finger protein BAP-1) (Protein DinG)

(Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting

protein 3)
RNF2 Gene names
RNF2 BAP1 DING HIPI3 RING1B
Organism
Human
RNF2 Entry name
RING2_HUMAN
RNF2 Codon optimized cDNA Clone
RNF2 CDNA Cat#
RPS0727
cDNA Tag
cDNA RNF2 Contains A 6x histidine tag
Condon optimized RNF2 CDNA Formulation
Liquid
Condon optimized RNF2 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized RNF2 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant RNF2 Protein
Recombinant RNF2 Protein Cat#
PS0727
RNF2 Protein Source
Recombinant protein.
Recombinant RNF2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant RNF2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant RNF2 Protein Activity
N/A
Recombinant protein Tag
Recombinant RNF2 contains A 6x histidine tag
Recombinant RNF2 Protein Formulation
Liquid
Recombinant RNF2 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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RNF2 Protein family
-
RNF2 Subcellular locations
Nucleus. Chromosome.
RNF2 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: E3 ubiquitin-protein ligase that mediates monoubiquitination of

'Lys-119' of histone H2A, thereby playing a central role in histone code and

gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for

epigenetic transcriptional repression and participates in X chromosome

inactivation of female mammals. May be involved in the initiation of both

imprinted and random X inactivation. Essential component of the Polycomb

group (PcG) multiprotein PRC1 complex, a complex required to maintain the

transcriptionally repressive state of many genes, including Hox genes,

throughout development. PcG PRC1 complex act via chromatin remodeling

and modification of histones, rendering chromatin heritably changed in its

expressibility. E3 ubiquitin-protein ligase activity is enhanced by

BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the

PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2

activity.
RNF2 Sequence databases
EMBL DDBJ GenBank
RNF2 3D structure databases
ModBase
RNF2 Protein-protein interaction databases
STRING
RNF2 Proteomic databases
PRIDE
RNF2 Genome annotation databases
Ensembl GeneID KEGG UCSC
RNF2 Organism specific databases
CTD MGI
RNF2 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
RNF2 Gene expression databases
Bgee ArrayExpress Genevestigator
RNF2 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY