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Human E3 ubiquitin-protein ligase NRDP1 (a.a.1-317)
RNF41 Swiss Prot#
Q9H4P4
RNF41 Protein names
E3 ubiquitin-protein ligase NRDP1 (EC 6.3.2.-) (RING finger protein 41)
RNF41 Gene names
RNF41 FLRF NRDP1 SBBI03
Organism
Human
RNF41 Entry name
RNF41_HUMAN
RNF41 Codon optimized cDNA Clone
RNF41 CDNA Cat#
RPS0728
cDNA Tag
cDNA RNF41 Contains A 6x histidine tag
Condon optimized RNF41 CDNA Formulation
Liquid
Condon optimized RNF41 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized RNF41 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant RNF41 Protein
Recombinant RNF41 Protein Cat#
PS0728
RNF41 Protein Source
Recombinant protein.
Recombinant RNF41 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant RNF41 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant RNF41 Protein Activity
N/A
Recombinant protein Tag
Recombinant RNF41 contains A 6x histidine tag
Recombinant RNF41 Protein Formulation
Liquid
Recombinant RNF41 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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RNF41 Protein family
-
RNF41 Subcellular locations
-
RNF41 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the

degradation of target proteins. Negatively regulates MYD88-dependent

production of proinflammatory cytokines but can promote TRIF-dependent

production of type I interferon. Promotes also activation of TBK1 and IRF3.

Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3)

receptors. Thus, through maintaining basal levels of cytokine receptors,

FLRF is involved in the control of hematopoietic progenitor cell

differentiation into myeloerythroid lineages (By similarity). Contributes to the

maintenance of steady-state ERBB3 levels by mediating its growth factor-

independent degradation. Involved in the degradation of the inhibitor of

apoptosis BIRC6 and thus is an important regulator of cell death by

promoting apoptosis. Acts also as a PARK2 modifier that accelerates its

degradation, resulting in a reduction of PARK2 activity, influencing the

balance of intracellular redox state.
RNF41 Sequence databases
EMBL DDBJ GenBank
RNF41 3D structure databases
ModBase
RNF41 Protein-protein interaction databases
STRING
RNF41 Proteomic databases
PRIDE
RNF41 Genome annotation databases
Ensembl GeneID KEGG UCSC
RNF41 Organism specific databases
CTD MGI
RNF41 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
RNF41 Gene expression databases
Bgee ArrayExpress Genevestigator
RNF41 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY