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Human Retinoic acid receptor RXR-alpha (a.a.1-462)
RXRA Swiss Prot#
P19793
RXRA Protein names
Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha) (Nuclear

receptor subfamily 2 group B member 1)
RXRA Gene names
RXRA NR2B1
Organism
Human
RXRA Entry name
RXRA_HUMAN
RXRA Codon optimized cDNA Clone
RXRA CDNA Cat#
RPS0741
cDNA Tag
cDNA RXRA Contains A 6x histidine tag
Condon optimized RXRA CDNA Formulation
Liquid
Condon optimized RXRA CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized RXRA cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant RXRA Protein
Recombinant RXRA Protein Cat#
PS0741
RXRA Protein Source
Recombinant protein.
Recombinant RXRA Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant RXRA Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant RXRA Protein Activity
N/A
Recombinant protein Tag
Recombinant RXRA contains A 6x histidine tag
Recombinant RXRA Protein Formulation
Liquid
Recombinant RXRA Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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RXRA Protein family
Nuclear hormone receptor family, NR2 subfamily
RXRA Subcellular locations
Nucleus.
RXRA FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as

heterodimers to their target response elements in response to their ligands,

all-trans or 9-cis retinoic acid, and regulate gene expression in various

biological processes. The RAR/RXR heterodimers bind to the retinoic acid

response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known

as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA

serves as a common heterodimeric partner for a number of nuclear

receptors. The RXR/RAR heterodimers bind to the retinoic acid response

elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-

DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a

multiprotein complex containing transcription corepressors that induce

histone acetylation, chromatin condensation and transcriptional

suppression. On ligand binding, the corepressors dissociate from the

receptors and associate with the coactivators leading to transcriptional

activation. The RXRA/PPARA heterodimer is required for PPARA

transcriptional activity on fatty acid oxidation genes such as ACOX1 and the

P450 system genes.
RXRA Sequence databases
EMBL DDBJ GenBank
RXRA 3D structure databases
ModBase
RXRA Protein-protein interaction databases
STRING
RXRA Proteomic databases
PRIDE
RXRA Genome annotation databases
Ensembl GeneID KEGG UCSC
RXRA Organism specific databases
CTD MGI
RXRA Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
RXRA Gene expression databases
Bgee ArrayExpress Genevestigator
RXRA Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY