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Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member
1 (a.a.1-515)
SMARCD1 Swiss Prot#
Q96GM5
SMARCD1 Protein names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin

subfamily D member 1 (SWI/SNF complex 60 kDa subunit) (60 kDa BRG-

1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A)
SMARCD1 Gene names
SMARCD1 BAF60A
Organism
Human
SMARCD1 Entry name
SMRD1_HUMAN
SMARCD1 Codon optimized cDNA Clone
SMARCD1 CDNA Cat#
RPS0781
cDNA Tag
cDNA SMARCD1 Contains A 6x histidine tag
Condon optimized SMARCD1 CDNA Formulation
Liquid
Condon optimized SMARCD1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized SMARCD1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant SMARCD1 Protein
Recombinant SMARCD1 Protein Cat#
PS0781
SMARCD1 Protein Source
Recombinant protein.
Recombinant SMARCD1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant SMARCD1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant SMARCD1 Protein Activity
N/A
Recombinant protein Tag
Recombinant SMARCD1 contains A 6x histidine tag
Recombinant SMARCD1 Protein Formulation
Liquid
Recombinant SMARCD1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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SMARCD1 Protein family
SMARCD family
SMARCD1 Subcellular locations
Nucleus.
SMARCD1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Involved in chromatin remodeling. Belongs to the neural

progenitors-specific chromatin remodeling complex (npBAF complex) and

the neuron-specific chromatin remodeling complex (nBAF complex). During

neural development a switch from a stem/progenitor to a post-mitotic

chromatin remodeling mechanism occurs as neurons exit the cell cycle and

become committed to their adult state. The transition from proliferating

neural stem/progenitor cells to post-mitotic neurons requires a switch in

subunit composition of the npBAF and nBAF complexes. As neural

progenitors exit mitosis and differentiate into neurons, npBAF complexes

which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for

homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or

DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF

complex is essential for the self-renewal/proliferative capacity of the

multipotent neural stem cells. The nBAF complex along with CREST plays a

role regulating the activity of genes essential for dendrite growth (By

similarity). Has a strong influence on the Vitamin D-mediated transcriptional

activity from an enhancer Vitamin D receptor element (VDRE). May be a link

between mammalian SWI-SNF-like chromatin remodeling complexes and

the vitamin D receptor (VDR) heterodimer. Mediates critical interactions

between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling

complex for transactivation. Also involved in vitamin D-coupled

transcription regulation via its association with the WINAC complex, a

chromatin-remodeling complex recruited by vitamin D receptor (VDR),

which is required for the ligand-bound VDR-mediated transrepression of the

CYP27B1 gene.
SMARCD1 Sequence databases
EMBL DDBJ GenBank
SMARCD1 3D structure databases
ModBase
SMARCD1 Protein-protein interaction databases
STRING
SMARCD1 Proteomic databases
PRIDE
SMARCD1 Genome annotation databases
Ensembl GeneID KEGG UCSC
SMARCD1 Organism specific databases
CTD MGI
SMARCD1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA