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Human Vacuolar-sorting protein SNF8 (a.a.1-258)

SNF8 Swiss Prot#

Q96H20

SNF8 Protein names

Vacuolar-sorting protein SNF8 (ESCRT-II complex subunit VPS22) (hVps22)

(ELL-associated protein of 30 kDa)

SNF8 Gene names

SNF8 EAP30

Organism

Human

SNF8 Entry name

SNF8_HUMAN

SNF8 Codon optimized cDNA Clone

SNF8 CDNA Cat#

RPS0794

cDNA Tag

cDNA SNF8 Contains A 6x histidine tag

Condon optimized SNF8 CDNA Formulation

Liquid

Condon optimized SNF8 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized SNF8 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant SNF8 Protein

Recombinant SNF8 Protein Cat#

PS0794

SNF8 Protein Source

Recombinant protein.

Recombinant SNF8 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant SNF8 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant SNF8 Protein Activity

N/A

Recombinant protein Tag

Recombinant SNF8 contains A 6x histidine tag

Recombinant SNF8 Protein Formulation

Liquid

Recombinant SNF8 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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SNF8 Protein family

SNF8 family

SNF8 Subcellular locations

Cytoplasm. Endosome membrane. Nucleus. Late endosome membrane.

SNF8 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Component of the endosomal sorting complex required for

transport II (ESCRT-II), which is required for multivesicular body (MVB)

formation and sorting of endosomal cargo proteins into MVBs. The MVB

pathway mediates delivery of transmembrane proteins into the lumen of the

lysosome for degradation. The ESCRT-II complex is probably involved in the

recruitment of the ESCRT-III complex. The ESCRT-II complex may also play

a role in transcription regulation by participating in derepression of

transcription by RNA polymerase II, possibly via its interaction with ELL.

Required for degradation of both endocytosed EGF and EGFR, but not for the

EGFR ligand-mediated internalization. It is also required for the degradation

of CXCR4.

SNF8 Sequence databases

EMBL

DDBJ

GenBank

SNF8 3D structure databases

ModBase

SNF8 Protein-protein interaction databases

STRING

SNF8 Proteomic databases

PRIDE

SNF8 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

SNF8 Organism specific databases

CTD

MGI

SNF8 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SNF8 Gene expression databases

Bgee

ArrayExpress

Genevestigator

SNF8 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY