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Human Transcription factor EB (a.a.1-476)

TFEB Swiss Prot#

P19484

TFEB Protein names

Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)

TFEB Gene names

TFEB BHLHE35

Organism

Human

TFEB Entry name

TFEB_HUMAN

TFEB Codon optimized cDNA Clone

TFEB CDNA Cat#

RPS0904

cDNA Tag

cDNA TFEB Contains A 6x histidine tag

Condon optimized TFEB CDNA Formulation

Liquid

Condon optimized TFEB CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized TFEB cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant TFEB Protein

Recombinant TFEB Protein Cat#

PS0904

TFEB Protein Source

Recombinant protein.

Recombinant TFEB Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant TFEB Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant TFEB Protein Activity

N/A

Recombinant protein Tag

Recombinant TFEB contains A 6x histidine tag

Recombinant TFEB Protein Formulation

Liquid

Recombinant TFEB Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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TFEB Protein family

MiT/TFE family

TFEB Subcellular locations

Cytoplasm. Nucleus.

TFEB FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Transcription factor that specifically recognizes and binds E-box

sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with

itself or with another MiT/TFE family member such as TFE3 or MITF. In

association with TFE3, activates the expression of CD40L in T-cells, thereby

playing a role in T-cell-dependent antibody responses in activated CD4(+) T-

cells and thymus-dependent humoral immunity. Specifically recognizes and

binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the

regulatory region of many lysosomal genes, leading to activate their

expression. It thereby plays a central role in expression of lysosomal genes.

Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in

the heavy-chain immunoglobulin enhancer. Plays a role in the signal

transduction processes required for normal vascularization of the placenta.

TFEB Sequence databases

EMBL

DDBJ

GenBank

TFEB 3D structure databases

ModBase

TFEB Protein-protein interaction databases

STRING

TFEB Proteomic databases

PRIDE

TFEB Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

TFEB Organism specific databases

CTD

MGI

TFEB Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TFEB Gene expression databases

Bgee

ArrayExpress

Genevestigator

TFEB Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY