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Human 52 kDa Ro protein (a.a.1-475)
TRIM21 Swiss Prot#
P19474
TRIM21 Protein names
52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52

kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif-containing

protein 21) (RING finger protein 81)
TRIM21 Gene names
TRIM21 RNF81 RO52 SSA1
Organism
Human
TRIM21 Entry name
RO52_HUMAN
TRIM21 Codon optimized cDNA Clone
TRIM21 CDNA Cat#
RPS0931
cDNA Tag
cDNA TRIM21 Contains A 6x histidine tag
Condon optimized TRIM21 CDNA Formulation
Liquid
Condon optimized TRIM21 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized TRIM21 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant TRIM21 Protein
Recombinant TRIM21 Protein Cat#
PS0931
TRIM21 Protein Source
Recombinant protein.
Recombinant TRIM21 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant TRIM21 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant TRIM21 Protein Activity
N/A
Recombinant protein Tag
Recombinant TRIM21 contains A 6x histidine tag
Recombinant TRIM21 Protein Formulation
Liquid
Recombinant TRIM21 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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TRIM21 Protein family
TRIM/RBCC family
TRIM21 Subcellular locations
Cytoplasm. Nucleus. Cytoplasm > P-body.
TRIM21 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: E3 ubiquitin-protein ligase whose activity is dependent on E2

enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin

ligase complex in cooperation with the E2 UBE2D2 that is used not only for

the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination.

Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3

ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A

TRIM21-containing SCF(SKP2)-like complex is shown to mediate

ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting

its degradation by the proteasome. Monoubiquitinates IKBKB that will

negatively regulates Tax-induced NF-kappa-B signaling. Negatively

regulates IFN-beta production post-pathogen recognition by polyubiquitin-

mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal

degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-

associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination,

which enhanced the ability of IRF8 to stimulate cytokine genes transcription

in macrophages. Plays a role in the regulation of the cell cycle progression.

Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein

particle present in all mammalian cells studied and composed of a single

polypeptide and one of four small RNA molecules. At least two isoforms are

present in nucleated and red blood cells, and tissue specific differences in

RO/SSA proteins have been identified. The common feature of these

proteins is their ability to bind HY RNAs.2.
TRIM21 Sequence databases
EMBL DDBJ GenBank
TRIM21 3D structure databases
ModBase
TRIM21 Protein-protein interaction databases
STRING
TRIM21 Proteomic databases
PRIDE
TRIM21 Genome annotation databases
Ensembl GeneID KEGG UCSC
TRIM21 Organism specific databases
CTD MGI
TRIM21 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
TRIM21 Gene expression databases
Bgee ArrayExpress Genevestigator
TRIM21 Family and domain databases
InterPro PROSITE ProtoNet