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Human Twist-related protein 1 (a.a.1-202)

TWIST1 Swiss Prot#

Q15672

TWIST1 Protein names

Twist-related protein 1 (H-twist) (Class A basic helix-loop-helix protein 38)

(bHLHa38)

TWIST1 Gene names

TWIST1 BHLHA38 TWIST

Organism

Human

TWIST1 Entry name

TWST1_HUMAN

TWIST1 Codon optimized cDNA Clone

TWIST1 CDNA Cat#

RPS0963

cDNA Tag

cDNA TWIST1 Contains A 6x histidine tag

Condon optimized TWIST1 CDNA Formulation

Liquid

Condon optimized TWIST1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized TWIST1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant TWIST1 Protein

Recombinant TWIST1 Protein Cat#

PS0963

TWIST1 Protein Source

Recombinant protein.

Recombinant TWIST1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant TWIST1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant TWIST1 Protein Activity

N/A

Recombinant protein Tag

Recombinant TWIST1 contains A 6x histidine tag

Recombinant TWIST1 Protein Formulation

Liquid

Recombinant TWIST1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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TWIST1 Protein family

TWIST1 Subcellular locations

Nucleus.

TWIST1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Acts as a transcriptional regulator. Inhibits myogenesis by

sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting

DNA-binding by MYOD1 through physical interaction. This interaction

probably involves the basic domains of both proteins. Also represses

expression of proinflammatory cytokines such as TNFA and IL1B. Regulates

cranial suture patterning and fusion. Activates transcription as a

heterodimer with E proteins. Regulates gene expression differentially,

depending on dimer composition. Homodimers induce expression of FGFR2

and POSTN while heterodimers repress FGFR2 and POSTN expression and

induce THBS1 expression. Heterodimerization is also required for

osteoblast differentiation.

TWIST1 Sequence databases

EMBL

DDBJ

GenBank

TWIST1 3D structure databases

ModBase

TWIST1 Protein-protein interaction databases

STRING

TWIST1 Proteomic databases

PRIDE

TWIST1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

TWIST1 Organism specific databases

CTD

MGI

TWIST1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TWIST1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

TWIST1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY